Understanding tumor changes through blood samples for better cancer treatment
Translating the tumor regulome from cell-free DNA for precision oncology
This study is looking at how to make cancer treatment better by checking for tiny bits of tumor DNA in the blood, especially for patients with advanced cancer who can't easily get tissue samples, so they can receive more tailored and effective treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Fred Hutchinson Cancer Center NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10473384 on NIH RePORTER |
What this research studies
This research focuses on improving cancer treatment by analyzing circulating tumor DNA (ctDNA) found in the blood of patients. It aims to develop new methods to identify changes in tumors that occur during treatment, especially for those with metastatic cancer who may not have easy access to tumor tissue. By examining the genetic and epigenetic factors in ctDNA, the study seeks to provide a more comprehensive understanding of tumor behavior and resistance to therapies. This non-invasive approach could lead to more personalized treatment options for patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with metastatic cancer who have limited access to tumor tissue for biopsies.
Not a fit: Patients with early-stage cancers or those who can easily access tumor tissue for biopsies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored cancer treatments based on real-time tumor analysis from blood samples.
How similar studies have performed: Other research has shown promise in using ctDNA for cancer monitoring, indicating that this approach could be a significant advancement in precision oncology.
Where this research is happening
Seattle, United States
- Fred Hutchinson Cancer Center — Seattle, United States (Active)
Researchers
- Principal investigator: Ha, Gavin — Fred Hutchinson Cancer Center
- Study coordinator: Ha, Gavin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.