Understanding Tuberous Sclerosis Complex and Lymphatic Vessels
TSC Proteins in the Lymphatic Vasculature
['FUNDING_R01'] · UNIVERSITY OF SOUTH FLORIDA · NIH-11114000
This research explores how changes in lymphatic vessels contribute to severe breathing problems in people with Tuberous Sclerosis Complex (TSC).
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTH FLORIDA (nih funded) |
| Locations | 1 site (TAMPA, UNITED STATES) |
| Trial ID | NIH-11114000 on ClinicalTrials.gov |
What this research studies
Tuberous Sclerosis Complex (TSC) is a lifelong condition causing tumors in various organs, and it currently has no cure. A serious complication for some patients is chylothorax, where milky fluid builds up around the lungs, making it hard to breathe and potentially leading to respiratory failure. While it's often thought that tumors simply press on lymphatic vessels, we want to find out if the TSC genetic changes directly affect these vessels themselves. By understanding how lymphatic vessels are involved in TSC, we hope to discover new ways to treat this challenging aspect of the disease.
Who could benefit from this research
Good fit: Patients with Tuberous Sclerosis Complex (TSC), especially those who experience chylothorax or related lymphatic complications, are the focus of this research.
Not a fit: Patients without Tuberous Sclerosis Complex or those whose symptoms are unrelated to lymphatic vessel dysfunction may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments specifically targeting lymphatic vessel issues in TSC patients, potentially preventing or alleviating severe breathing difficulties like chylothorax.
How similar studies have performed: Preliminary findings in mouse models suggest a direct link between TSC genes and lymphatic vessel issues, indicating a promising new direction for understanding chylothorax in TSC.
Where this research is happening
TAMPA, UNITED STATES
- UNIVERSITY OF SOUTH FLORIDA — TAMPA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YANG, YING — UNIVERSITY OF SOUTH FLORIDA
- Study coordinator: YANG, YING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bourneville Disease, Bourneville syndrome