Understanding TRIO gene changes in autism and related conditions
Dysregulation of TRIO GEF1 activity in neurodevelopmental disorders
This work looks at how changes in a gene called TRIO might lead to conditions like autism and intellectual disability, hoping to find new ways to help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-11093497 on NIH RePORTER |
What this research studies
Our bodies have a gene called TRIO, and certain changes in this gene are linked to neurodevelopmental disorders such as autism and schizophrenia. We've found specific changes in TRIO that either boost or slow down a part of the gene called GEF1, which seems important for brain development. This project aims to uncover exactly how TRIO GEF1 activity is controlled and what happens when it doesn't work correctly. By understanding these basic mechanisms, we hope to learn how TRIO gene changes cause these disorders and identify new targets for treatments.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients but focuses on understanding genetic causes relevant to individuals with autism, schizophrenia, and intellectual disability.
Not a fit: Patients not affected by genetic changes in the TRIO gene may not directly benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could reveal fundamental causes of neurodevelopmental disorders and lead to new ideas for therapies.
How similar studies have performed: While the specific mechanisms of TRIO GEF1 regulation are not fully understood, other genetic studies have successfully identified gene variants linked to neurodevelopmental disorders.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Koleske, Anthony J — Yale University
- Study coordinator: Koleske, Anthony J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.