Understanding Tracheal Esophageal Birth Defects
Project-1: Comprehensive phenotypic and genetic assessment of TE birth defects in patients
This project aims to better understand the causes and outcomes of tracheal esophageal birth defects (TEDs) in children.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11121913 on NIH RePORTER |
What this research studies
Tracheal esophageal birth defects (TEDs) happen when the windpipe and food pipe don't separate correctly before birth, leading to breathing and feeding problems. Even after surgery, children with TEDs often face long-term health issues. This project seeks to uncover the specific genetic changes that cause TEDs and how these changes affect a child's unique anatomy and health outcomes. By collecting detailed information on genetics, anatomy, and clinical history from many patients, we hope to predict how children with TEDs will fare and improve their treatment strategies.
Who could benefit from this research
Good fit: This project focuses on patients who have been diagnosed with tracheal esophageal birth defects (TEDs).
Not a fit: Patients without tracheal esophageal birth defects would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier diagnosis, more personalized treatment plans, and better long-term health for children born with tracheal esophageal birth defects.
How similar studies have performed: While some genetic links to TEDs have been found, this project represents a novel, large-scale effort to comprehensively investigate the genetic, anatomical, and clinical aspects of this patient population.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Chung, Wendy K — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Chung, Wendy K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.