Understanding Trachea-Esophageal Birth Defects in Newborns
CLEAR Consortium: Discovering the Developmental Mechanisms of Trachea-Esophageal Birth Defects
This project aims to learn more about why trachea and esophagus birth defects happen in babies, so we can find better ways to help them.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project ID | NIH-11121905 on NIH RePORTER |
What this research studies
This project brings together doctors and scientists to understand birth defects where a baby's breathing tube (trachea) and feeding tube (esophagus) don't form correctly. These defects can make it hard for newborns to breathe and eat. Our team uses advanced tools like genetic testing from patients, special MRI scans of newborns, and studies of human stem cells to learn how these problems develop. We hope this work will lead to better ways to diagnose these conditions, improve treatments, and even explore new ways to grow replacement tissues in the future.
Who could benefit from this research
Good fit: Ideal candidates for this research would be newborn infants affected by trachea-esophageal birth defects and their families who may contribute genetic information or participate in observational studies.
Not a fit: Patients who do not have trachea-esophageal birth defects would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to earlier and more accurate diagnoses, improved treatments, and potentially new methods for tissue repair for babies born with trachea-esophageal birth defects.
How similar studies have performed: While gene mutations are known to cause some trachea-esophageal defects, this project aims to address the majority of cases where the cause is unknown, using a novel, multi-disciplinary approach.
Where this research is happening
Cincinnati, United States
- Cincinnati Childrens Hosp Med Ctr — Cincinnati, United States (Active)
Researchers
- Principal investigator: Zorn, Aaron M — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Zorn, Aaron M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.