Understanding TPH1 in Advanced Prostate Cancer
Elucidating the Role of Tryptophan Hydroxylase 1 in Neuroendocrine Prostate Cancer
This project explores a specific enzyme called TPH1 to find new ways to treat a very aggressive type of prostate cancer known as neuroendocrine prostate cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington State University NIH-funded |
| Lab location | 1 site (Pullman, United States) |
| Project ID | NIH-11087560 on NIH RePORTER |
What this research studies
Neuroendocrine prostate cancer (NEPC) is a very serious and often deadly form of prostate cancer that is becoming more common, especially after certain treatments for other prostate cancers. Currently, there are not many effective treatments for NEPC, and patients often have a very poor prognosis. This project aims to understand how an enzyme called TPH1 contributes to the development and growth of NEPC. Researchers believe that by targeting TPH1, they might be able to stop the cancer from growing and spreading, potentially leading to new treatment options.
Who could benefit from this research
Good fit: Patients with neuroendocrine prostate cancer, especially those whose cancer has become resistant to standard treatments, are the focus of this research.
Not a fit: Patients with early-stage or non-neuroendocrine forms of prostate cancer may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, targeted therapies for neuroendocrine prostate cancer, potentially improving patient survival.
How similar studies have performed: Preliminary studies by the researchers have shown that inhibiting TPH1 can repress cancer growth in laboratory and animal models, suggesting a promising new direction.
Where this research is happening
Pullman, United States
- Washington State University — Pullman, United States (Active)
Researchers
- Principal investigator: Wu, Boyang — Washington State University
- Study coordinator: Wu, Boyang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.