Understanding tongue development issues in a mouse model of Down syndrome
Tongue maturation deficits in a mouse model of Down syndrome
This study is looking at how Down syndrome affects the growth of the tongue and brainstem, which are important for talking and eating, using mice to help us learn more about the challenges people with Down syndrome face in these areas, especially during early childhood.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11145383 on NIH RePORTER |
What this research studies
This research investigates how Down syndrome affects the development of the tongue and brainstem, which are crucial for speech and swallowing. Using mouse models, the study aims to uncover the delays in tongue maturation that can lead to significant challenges in communication and feeding for individuals with Down syndrome. By generating normative data, the research seeks to better understand the neuromuscular changes that occur during early childhood, a critical period for development. The findings could provide insights into how altered tongue function impacts overall health and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with Down syndrome, particularly those experiencing difficulties with speech and swallowing.
Not a fit: Patients without Down syndrome or those who do not exhibit oromotor development issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved interventions for speech and feeding challenges in children with Down syndrome.
How similar studies have performed: While this research explores a relatively novel area, previous studies have shown that understanding developmental delays in similar conditions can lead to significant advancements in treatment.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Glass, Tiffany — University of Wisconsin-Madison
- Study coordinator: Glass, Tiffany
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.