Understanding tissue changes in glioma through MRI analysis
Official title: MOSAIC: Administrative Core
Funded at Mayo Clinic Arizona · NIH-10930912 · Data updated 2026-11-12
This study is looking at how glioma tumors change over time by using MRI scans and tissue samples from patients, so we can better understand the disease and improve treatment options for those affected.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Arizona NIH-funded |
| Lab location | 1 site (Scottsdale, United States) |
| Project start | September 18, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $296,618 |
| NIH project number | 5U54CA274504-02 |
| Project ID | NIH-10930912 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with glioma who are undergoing biopsy procedures.
✕Less likely to help
Patients with other types of cancers or those not undergoing biopsy procedures may not benefit from this research.
What this research studies
This research aims to develop a framework for understanding how glioma tissues change over time and how these changes can be interpreted using magnetic resonance imaging (MRI). The project involves collecting and analyzing biopsies from glioma patients, integrating imaging data with biological samples to enhance understanding of the disease. The administrative core will coordinate these efforts, ensuring efficient collaboration among various research teams and supporting the overall research process. Patients' biopsies will be crucial for this analysis, contributing to a better understanding of glioma progression and treatment.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment strategies for glioma patients.
How similar studies have gone: Previous research has shown promise in using imaging techniques to understand tumor biology, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Mayo Clinic Arizona
Scottsdale, United States Active
Researchers
- Principal investigator: Swanson, Kristin R — Mayo Clinic Arizona
- Study coordinator: Swanson, Kristin R
Related research
Other NIH-funded projects on the same topics.
-
Predicting Pain Recovery with a Multimodal AI using Harmonized Health Records
Aging patients with headaches will be helped by a new AI tool that uses medical records and brain images from Mayo Clinic and VA to predict who might have persistent pain.
-
Understanding immune signals in ALS to guide future therapies
A Mayo Clinic team will study how the immune system sees proteins in the brain of people with ALS and related conditions, to find clues for better treatments.
-
Determinants of Pathogenic Anti-PF4 Antibody–Mediated Platelet Activation
This project looks at why certain anti-PF4 antibodies in people cause harmful blood clots and how to better diagnose and treat those cases.
-
Understanding how a type of immune cell called ILC2s affect asthma in adults
This grant studies how group 2 innate lymphoid cells influence asthma in adults to help identify new ways to manage airway inflammation.
-
EHMT1 Variants and Kleefstra Syndrome: How Structure Shapes Neurodevelopmental Risks
A small NIH grant will explore how genetic changes in EHMT1 affect brain development in Kleefstra Syndrome using computer models and analysis of protein structure.
-
Targeting epigenomic regulators to assault pancreatic cancer replication stress
This research tests a new way to treat pancreatic cancer by blocking key epigenetic regulators during DNA replication to make cancer cells less able to cope with replication stress.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.