Understanding Tiny RNA Fragments and Their Role in Health
Developing C. elegans as a model to understand tRNA-fragment biogenesis and function
['FUNDING_OTHER'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-11101103
This project explores how tiny RNA fragments, called tRFs, are made and what they do in the body, using a small worm as a model.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-11101103 on ClinicalTrials.gov |
What this research studies
Our bodies contain tiny RNA fragments, called tRFs, that seem to play a part in many important processes, including aging and various diseases. We don't fully understand how these tRFs are created or what their exact jobs are in different parts of the body. This project uses a simple roundworm, C. elegans, to help us uncover these basic biological secrets. By studying these worms, we hope to learn more about how tRFs work, which could eventually help us understand human health and disease better.
Who could benefit from this research
Good fit: Patients with conditions such as cancer, neurodegenerative diseases, or those interested in aging research may find the future implications of this basic science relevant.
Not a fit: Patients seeking immediate new treatments or direct clinical trial participation will not find direct benefit from this foundational laboratory research.
Why it matters
Potential benefit: If successful, this work could provide fundamental insights into how tRFs contribute to conditions like cancer, neurodegenerative diseases, and aging, potentially leading to new ways to address these health challenges.
How similar studies have performed: While tRFs have been linked to various diseases, the specific mechanisms of their creation and function are still largely unknown, making this a novel exploration into their basic biology.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONINE, COLIN — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: CONINE, COLIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.