Understanding tiny cell signals in children with severe infections
Biobank of small extracellular vesicles for pediatric sepsis
['FUNDING_OTHER'] · CINCINNATI CHILDRENS HOSP MED CTR · NIH-11327919
This project collects tiny particles from the blood of children with severe infections to find better ways to understand and treat their illness.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CINCINNATI CHILDRENS HOSP MED CTR (nih funded) |
| Locations | 1 site (CINCINNATI, UNITED STATES) |
| Trial ID | NIH-11327919 on ClinicalTrials.gov |
What this research studies
Sepsis is a serious condition where the body overreacts to an infection, sometimes causing organs to fail. Because sepsis affects each child differently, finding the right treatment can be challenging. We are collecting tiny particles called small extracellular vesicles (sEVs) from the blood of children with sepsis. These sEVs carry messages from different parts of the body and can tell us which organs are affected and how. By studying these messages, we hope to discover unique patterns that could lead to more personalized and effective treatments for children with sepsis.
Who could benefit from this research
Good fit: Ideal candidates are children aged 0-11 years old who are experiencing sepsis and its complications.
Not a fit: Patients who do not have sepsis or are outside the pediatric age range would not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could help doctors better understand why sepsis affects children differently and lead to new, tailored treatments for organ failure caused by severe infections.
How similar studies have performed: The use of extracellular vesicles as biomarkers is a growing field, with preliminary data suggesting their potential in understanding inflammatory responses in sepsis.
Where this research is happening
CINCINNATI, UNITED STATES
- CINCINNATI CHILDRENS HOSP MED CTR — CINCINNATI, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZINGARELLI, BASILIA — CINCINNATI CHILDRENS HOSP MED CTR
- Study coordinator: ZINGARELLI, BASILIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.