Understanding the Y Chromosome's Impact on Bladder Cancer in Men
The Role of the Y Chromosome in Bladder Tumor Development, Growth And Progression
This research explores how the loss of the Y chromosome in men affects the way bladder cancer grows and spreads.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11141043 on NIH RePORTER |
What this research studies
For men with bladder cancer, losing the Y chromosome in tumor cells is common, but we don't fully understand why or what it means for their health. This project aims to uncover the specific ways that losing the Y chromosome influences how bladder tumors grow and become more aggressive. By understanding these underlying biological processes, we hope to find new ways to help men with bladder cancer. We are looking at genetic information from tumors and using laboratory models to see how these changes affect cancer progression.
Who could benefit from this research
Good fit: This foundational research focuses on men with bladder cancer, particularly those whose tumors show a loss of the Y chromosome.
Not a fit: Patients without bladder cancer or those whose tumors do not exhibit Y chromosome loss may not directly benefit from this specific line of inquiry.
Why it matters
Potential benefit: If successful, this work could lead to new treatments or ways to predict how bladder cancer will behave in men, potentially improving outcomes.
How similar studies have performed: While the association between Y chromosome loss and cancer risk is known, the specific biological mechanisms driving bladder cancer growth due to this loss are largely unknown, making this a novel area of focus.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Theodorescu, Dan — Cedars-Sinai Medical Center
- Study coordinator: Theodorescu, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.