Understanding the Wnt Pathway in Cancer
Genetic and Molecular Dissection of Wnt Pathway Activation
['FUNDING_OTHER'] · DARTMOUTH COLLEGE · NIH-11090170
This project explores how a crucial cell communication pathway, called Wnt, works in the body and how problems with it can lead to cancers like colorectal cancer.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DARTMOUTH COLLEGE (nih funded) |
| Locations | 1 site (HANOVER, UNITED STATES) |
| Trial ID | NIH-11090170 on ClinicalTrials.gov |
What this research studies
Our bodies rely on a communication system called the Wnt pathway for healthy growth and repair. When this system doesn't work correctly, it can cause various health problems, including many cancers, especially colorectal cancer. Currently, we don't have many effective treatments for diseases caused by Wnt pathway issues. This research uses fruit flies to uncover the basic steps of how the Wnt pathway functions. By understanding these fundamental mechanisms, we hope to discover new weaknesses in the pathway that could be targeted by future medicines.
Who could benefit from this research
Good fit: Patients with Wnt-driven diseases, particularly colorectal cancer, could potentially benefit from future therapies developed from this foundational understanding.
Not a fit: Patients whose conditions are not related to the Wnt signaling pathway are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new drugs and treatments for Wnt-driven diseases, including colorectal cancer and certain developmental disorders.
How similar studies have performed: This research builds upon previous discoveries by the principal investigator's group regarding the Wnt pathway and the role of the APC tumor suppressor.
Where this research is happening
HANOVER, UNITED STATES
- DARTMOUTH COLLEGE — HANOVER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AHMED, YASMATH — DARTMOUTH COLLEGE
- Study coordinator: AHMED, YASMATH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.