Understanding the vascular changes in Alzheimer's disease through imaging and biomarkers
Official title: ARIA Pathophysiology Characterized by in vivo Neuroimaging, Plasma Biomarkers and Post-Mortem Proteomics
Funded at New York University School of Medicine · NIH-11099384 · Data updated 2026-11-12
This study is looking at how changes in blood vessels in the brain relate to memory and thinking problems in people with Alzheimer's disease, and it will track patients over time to see how these changes are affected by new treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 4, 2025 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $3,310,951 |
| NIH project number | 1U24NS141774-01 |
| Project ID | NIH-11099384 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias who are undergoing anti-amyloid antibody treatment.
✕Less likely to help
Patients with other forms of dementia not related to amyloid pathology may not benefit from this research.
What this research studies
This research investigates the vascular pathophysiology associated with amyloid-related imaging abnormalities (ARIA) in Alzheimer's disease. It aims to develop and validate advanced MRI imaging protocols and analytical tools to link neuroimaging findings with clinical symptoms and cognitive functions. Patients will be followed over time, both before and after treatment with anti-amyloid antibodies, to assess changes in brain vascular health and its relation to cognitive decline. The study involves a multi-disciplinary team of experts to ensure comprehensive analysis and understanding of the disease.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for Alzheimer's disease and related dementias.
How similar studies have gone: Previous research has shown promise in using advanced imaging techniques to understand Alzheimer's disease, indicating that this approach may yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Wisniewski, Thomas M — New York University School of Medicine
- Study coordinator: Wisniewski, Thomas M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.