Understanding the TRPV3 Channel's Shape and How It Works
Structure and Function of a Pentameric TRPV3 Channel
This project explores a newly found shape of a protein called TRPV3, which is important for many body functions and could be a target for new medicines.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11134586 on NIH RePORTER |
What this research studies
We are looking closely at a protein called TRPV3, which acts like a tiny gate in our cells and is involved in various body processes. Scientists have found that this protein can exist in different shapes, and we've recently discovered a new five-part (pentameric) shape that might explain how the gate sometimes opens wider. Our goal is to connect this new shape to how the protein functions, determine its detailed structure, and see if certain disease-causing changes in TRPV3 lead to this new shape more often. This work uses advanced microscopy to visualize these tiny structures and understand their behavior.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but future studies building on this knowledge could seek patients with conditions linked to TRPV3 channel dysfunction.
Not a fit: Patients not interested in the basic science of protein structure and function would not find direct benefit from this specific grant.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how TRPV3 channels contribute to disease and help in designing new drugs that specifically target these channels.
How similar studies have performed: While many TRP channel structures have been determined, the discovery of a pentameric state for TRPV3 and its potential link to pore-dilation is a novel aspect of this research.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Scheuring, Simon — Weill Medical Coll of Cornell Univ
- Study coordinator: Scheuring, Simon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.