Understanding the transition from normal aging to Alzheimer's disease
Core F: University of Kentucky Alzheimer's Disease Core Center
This study is looking for helpful signs in blood, brain fluid, and brain scans to better understand how Alzheimer's and other types of dementia progress, while also using wearable devices to track sleep and activity, all to improve future treatments for people facing these challenges.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project ID | NIH-10880731 on NIH RePORTER |
What this research studies
This research focuses on identifying and characterizing biomarkers that can help track the progression of Alzheimer's disease and other forms of dementia. By using a multimodal approach, the study will analyze various biological markers from blood, cerebrospinal fluid, and advanced imaging techniques to understand cognitive decline better. Additionally, wearable devices will be utilized to monitor sleep and physical activity, providing a comprehensive view of how these factors relate to dementia. The goal is to develop a clearer picture of the transitions from normal cognitive function to dementia, which could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing cognitive changes or those at risk for Alzheimer's disease due to age or family history.
Not a fit: Patients with advanced Alzheimer's disease or those not experiencing any cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and more effective interventions for Alzheimer's disease and related dementias.
How similar studies have performed: Previous research has shown promise in using multimodal biomarker approaches to understand dementia progression, indicating that this method could yield valuable insights.
Where this research is happening
Lexington, United States
- University of Kentucky — Lexington, United States (Active)
Researchers
- Principal investigator: Wilcock, Donna M — University of Kentucky
- Study coordinator: Wilcock, Donna M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.