Understanding the transition from normal aging to Alzheimer's disease
Neuropath Core
This study is looking at how normal aging can lead to mild cognitive impairment and Alzheimer's disease, focusing on how things like metabolism and blood vessel health play a role, and it aims to improve research by collecting brain samples and encouraging donations from diverse communities.
Quick facts
| Grant type | P30 center grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10874735 on NIH RePORTER |
What this research studies
This research focuses on the transitions from normal aging to mild cognitive impairment (MCI) and Alzheimer's disease (AD), investigating the role of metabolic and vascular risk factors in these changes. The Neuropathology Core will collect, store, and distribute brain and other biospecimens to support innovative research in Alzheimer's disease. It will also establish neuropathological diagnoses and utilize non-human primate models for critical mechanistic and therapeutic studies. Additionally, the Core aims to enhance brain donation from underrepresented groups to address health disparities in Alzheimer's research.
Who could benefit from this research
Good fit: Ideal candidates for participation include individuals experiencing normal aging, mild cognitive impairment, or early stages of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for Alzheimer's disease and related disorders.
How similar studies have performed: Previous research has shown success in understanding Alzheimer's disease through similar approaches, particularly in the use of biospecimens and animal models.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Montine, Thomas J — Wake Forest University Health Sciences
- Study coordinator: Montine, Thomas J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.