Understanding the SYK-CARD9 Pathway in Alzheimer's Disease
Role of the SYK-CARD9 signaling axis in Alzheimer's disease
This research explores how specific immune signals in the brain contribute to Alzheimer's disease, hoping to uncover new ways to help patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Virginia NIH-funded |
| Lab location | 1 site (Charlottesville, United States) |
| Project ID | NIH-11113967 on NIH RePORTER |
What this research studies
We know that immune cells in the brain play a big part in Alzheimer's disease, but we don't fully understand how they work. This project looks at a specific communication pathway, called SYK-CARD9, inside these immune cells. By understanding how this pathway affects the disease, we hope to find new targets for medicines. Our early findings suggest this pathway is important for clearing harmful proteins and protecting brain function, and disrupting it can worsen cognitive decline.
Who could benefit from this research
Good fit: This foundational research is relevant to anyone affected by Alzheimer's disease or other age-related dementias.
Not a fit: Patients seeking immediate treatment options may not directly benefit from this early-stage basic science research.
Why it matters
Potential benefit: If successful, this work could identify new targets for medications that slow down or prevent the progression of Alzheimer's disease.
How similar studies have performed: While the specific role of SYK-CARD9 in Alzheimer's is still being determined, related studies have shown these immune receptors are involved in disease progression, and preliminary findings from this team support its importance.
Where this research is happening
Charlottesville, United States
- University of Virginia — Charlottesville, United States (Active)
Researchers
- Principal investigator: Lukens, John R — University of Virginia
- Study coordinator: Lukens, John R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.