Understanding the survival and potential of insulin-deficient beta cells in type 1 diabetes
Survival and potential of insulin-deficient beta cells in type 1 diabetes
This study is looking at special cells in the pancreas of people with type 1 diabetes that used to make insulin but don’t anymore, to see how they work and if they could help us find new treatments for diabetes.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10891592 on NIH RePORTER |
What this research studies
This research investigates the presence of 'empty' beta cells in the pancreas of patients with type 1 diabetes, which are cells that no longer produce insulin but still show signs of being active. The study aims to understand the mechanisms behind these cells and their potential role in diabetes progression. Using advanced imaging techniques, researchers will analyze various cell markers in pancreatic tissues from individuals with type 1 diabetes, type 2 diabetes, and non-diabetic controls. This comprehensive approach may reveal insights into how these empty beta cells could be targeted for therapeutic interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with recent-onset type 1 diabetes.
Not a fit: Patients with type 2 diabetes or those who have had type 1 diabetes for an extended period may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that restore insulin production in patients with type 1 diabetes.
How similar studies have performed: Other research has shown promising results in understanding beta cell function and potential therapeutic targets in diabetes, making this approach both relevant and potentially impactful.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Schatz, Desmond Arthur — University of Florida
- Study coordinator: Schatz, Desmond Arthur
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.