Understanding the structures of amyloid-beta oligomers in Alzheimer's disease
Characterizing Alzheimer's Amyloid-beta Oligomer Structures by Solid-State NMR and Cryo-Electron Microscopy
This study is looking at tiny protein clusters linked to Alzheimer's disease to understand how they form and behave, which could help create better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11212125 on NIH RePORTER |
What this research studies
This research investigates the structures of amyloid-beta (Aβ) oligomers, which are small aggregates of proteins associated with Alzheimer's disease. By using advanced techniques like solid-state nuclear magnetic resonance (NMR) and cryo-electron microscopy, the researchers aim to identify the different forms these oligomers can take and how they differ from larger aggregates known as fibrils. The goal is to gain insights into the mechanisms of Aβ assembly, which could inform the development of targeted therapies for Alzheimer's disease. Patients may benefit from a better understanding of the disease's underlying biology, potentially leading to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it.
Not a fit: Patients with other forms of dementia unrelated to amyloid-beta pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease by identifying specific oligomer structures to target.
How similar studies have performed: Previous research has shown promise in understanding amyloid-beta aggregation, but this specific approach to characterizing oligomer structures is relatively novel.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Paravastu, Anant Krishna — Georgia Institute of Technology
- Study coordinator: Paravastu, Anant Krishna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.