Understanding the structure of perineuronal nets in the brain
The molecular architecture of perineuronal nets
['FUNDING_R01'] · UPSTATE MEDICAL UNIVERSITY · NIH-10842260
This study is looking at special structures in the brain called perineuronal nets, which help with thinking and can be linked to brain disorders, to find out what proteins make them up and how they work with brain cells, with the hope of discovering new ways to help people with these conditions.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UPSTATE MEDICAL UNIVERSITY (nih funded) |
| Locations | 1 site (SYRACUSE, UNITED STATES) |
| Trial ID | NIH-10842260 on ClinicalTrials.gov |
What this research studies
This research investigates the molecular architecture of perineuronal nets (PNNs), which are important structures in the brain that support cognitive functions and are involved in various neurological disorders. The study aims to identify the specific proteins that make up these nets and how they interact with neurons. By using advanced laboratory techniques both in vitro and in vivo, the researchers hope to uncover the mechanisms by which PNNs influence neural activity and development. This understanding could lead to new therapeutic strategies for conditions where PNNs are altered.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with neurological disorders that may be linked to alterations in cognitive function and neural plasticity.
Not a fit: Patients with conditions unrelated to neural development or cognitive function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for neurological disorders by targeting the mechanisms that involve perineuronal nets.
How similar studies have performed: While the study of perineuronal nets is a growing field, the specific approach of identifying unique components and receptors is relatively novel and has not been extensively tested.
Where this research is happening
SYRACUSE, UNITED STATES
- UPSTATE MEDICAL UNIVERSITY — SYRACUSE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MATTHEWS, RUSSELL T. — UPSTATE MEDICAL UNIVERSITY
- Study coordinator: MATTHEWS, RUSSELL T.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.