Understanding the structure of immune responses in tuberculosis lymphadenitis
Official title: Cellular and molecular architecture of granulomas in human tuberculous lymphadenitis
Funded at Institut Pasteur de Tunis · NIH-11080957 · Data updated 2026-11-12
This study is looking at the tiny structures in the lymph nodes of people with tuberculous lymphadenitis to find new ways to diagnose and understand this type of tuberculosis, and it’s being done by researchers from the Institut Pasteur de Tunis and UCLA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institut Pasteur de Tunis NIH-funded |
| Lab location | 1 site (Tunis, Tunisia) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $144,940 |
| NIH project number | 5R01AI169526-03 |
| Project ID | NIH-11080957 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with tuberculous lymphadenitis, particularly those in Tunisia.
✕Less likely to help
Patients with other forms of tuberculosis or those without lymphadenitis may not benefit from this research.
What this research studies
This research investigates the cellular and molecular structure of granulomas in patients with tuberculous lymphadenitis, a common form of tuberculosis affecting lymph nodes. By analyzing lymph node specimens through advanced techniques like single cell RNA sequencing and spatial sequencing, the study aims to uncover biomarkers that could help in diagnosing and understanding the disease. The research is conducted in collaboration between the Institut Pasteur de Tunis and UCLA, focusing on how T cell responses influence antimicrobial activity within granulomas.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with tuberculous lymphadenitis.
How similar studies have gone: While the approach of using advanced sequencing techniques is gaining traction, the specific focus on granulomas in tuberculous lymphadenitis represents a novel area of investigation.
Where this research is happening
-
Institut Pasteur de Tunis
Tunis, Tunisia Active
Researchers
- Principal investigator: Benabdessalem, Chaouki — Institut Pasteur de Tunis
- Study coordinator: Benabdessalem, Chaouki
Related research
Other NIH-funded projects on the same topics.
-
Granulomas in tuberculous lymph node disease: how immune cells organize to fight TB
Researchers will study how immune cells organize inside granulomas in tuberculous lymphadenitis to uncover clues for better diagnosis and treatment.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.