Understanding the structure of immune responses in tuberculosis lymphadenitis
Cellular and molecular architecture of granulomas in human tuberculous lymphadenitis
This study is looking at the tiny structures in the lymph nodes of people with tuberculous lymphadenitis to find new ways to diagnose and understand this type of tuberculosis, and it’s being done by researchers from the Institut Pasteur de Tunis and UCLA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Institut Pasteur de Tunis NIH-funded |
| Lab location | 1 site (Tunis, Tunisia) |
| Project ID | NIH-11080957 on NIH RePORTER |
What this research studies
This research investigates the cellular and molecular structure of granulomas in patients with tuberculous lymphadenitis, a common form of tuberculosis affecting lymph nodes. By analyzing lymph node specimens through advanced techniques like single cell RNA sequencing and spatial sequencing, the study aims to uncover biomarkers that could help in diagnosing and understanding the disease. The research is conducted in collaboration between the Institut Pasteur de Tunis and UCLA, focusing on how T cell responses influence antimicrobial activity within granulomas.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with tuberculous lymphadenitis, particularly those in Tunisia.
Not a fit: Patients with other forms of tuberculosis or those without lymphadenitis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with tuberculous lymphadenitis.
How similar studies have performed: While the approach of using advanced sequencing techniques is gaining traction, the specific focus on granulomas in tuberculous lymphadenitis represents a novel area of investigation.
Where this research is happening
Tunis, Tunisia
- Institut Pasteur de Tunis — Tunis, Tunisia (Active)
Researchers
- Principal investigator: Benabdessalem, Chaouki — Institut Pasteur de Tunis
- Study coordinator: Benabdessalem, Chaouki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.