Understanding the structure of human islets to improve diabetes treatment
Linking human islet structural heterogeneity to beta cell state
['FUNDING_U01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10891735
This study is looking at how the tiny clusters of cells in the pancreas, which help make insulin, are organized and how that affects their function, with the hope of finding better treatments for type 1 diabetes that could help keep these important cells healthy.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10891735 on ClinicalTrials.gov |
What this research studies
This research investigates the complex structure of human islets, which are clusters of cells in the pancreas that play a crucial role in insulin production. By using advanced 3D imaging techniques, the team aims to identify key features of islet organization and how these features affect beta cell function. The goal is to enhance the development of stem-cell derived islets, potentially providing a new treatment for type 1 diabetes and preventing the loss of beta cells in diabetic patients. Patients may benefit from insights that could lead to improved therapies for diabetes management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 1 diabetes or those at risk of developing the condition.
Not a fit: Patients with type 2 diabetes or those whose diabetes is not related to beta cell dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that restore insulin production in patients with type 1 diabetes.
How similar studies have performed: Previous research has shown promise in using 3D imaging to understand islet structure, suggesting that this approach could yield valuable insights.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SNEDDON, JULIE BETH — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: SNEDDON, JULIE BETH
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.