Understanding the structure of bacterial DNA
Official title: Physical model of the bacteria nucleoid
Funded at University of Minnesota · NIH-11092737 · Data updated 2026-11-12
This study looks at how bacteria keep their DNA neatly organized, which is important for their health, and by understanding this better, we hope to find ways to support good bacteria and fight off bad ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | June 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $341,070 |
| NIH project number | 5R01GM149501-02 |
| Project ID | NIH-11092737 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with infections caused by pathogenic bacteria or those interested in microbiome health.
✕Less likely to help
Patients with viral infections or non-bacterial health issues may not receive any benefit from this research.
What this research studies
This research investigates how bacterial DNA is organized into a compact structure called the nucleoid, which is essential for bacterial health. By exploring the interactions between DNA and proteins, the study aims to uncover the physical principles that govern the nucleoid's formation and maintenance. The researchers will utilize a combination of experimental data and physical modeling to better understand the dynamics of DNA within bacteria. This knowledge could help in promoting beneficial bacteria and combating harmful pathogens.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing beneficial bacteria and targeting harmful pathogens.
How similar studies have gone: While the approach of linking nucleoid biology to polymer physics is innovative, similar studies have shown promise in understanding bacterial behavior and could provide a foundation for this research.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Dorfman, Kevin D — University of Minnesota
- Study coordinator: Dorfman, Kevin D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.