Understanding the structure of amyloid fibrils in neurodegenerative diseases and aging
Official title: Structure of amyloid fibrils in human neurodegenerative diseases and aging
Funded at Indiana University Indianapolis · NIH-10721721 · Data updated 2026-11-12
This study is looking at the tiny structures of proteins that build up in the brains of people with Alzheimer's and Parkinson's, hoping to find new ways to diagnose and treat these conditions so that patients can have better care and understanding of their diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 30, 2018 |
| Project end | August 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $3,924,261 |
| NIH project number | 2RF1NS110437-06 |
| Project ID | NIH-10721721 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Alzheimer's disease, Parkinson's disease, or other related neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases not related to amyloid fibrils or those without a confirmed diagnosis may not benefit from this research.
What this research studies
This research investigates the atomic structures of amyloid fibrils associated with neurodegenerative diseases like Alzheimer's and Parkinson's. By analyzing brain tissue, the study aims to characterize the morphology of tau filaments and other amyloid structures at a high resolution. The findings could lead to the development of new diagnostic tools and treatments by understanding how these proteins contribute to neurodegeneration. Patients may benefit from insights into the mechanisms of their conditions and potential new therapeutic approaches.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic methods and targeted therapies for neurodegenerative diseases.
How similar studies have gone: Previous research has shown promising results in understanding amyloid structures and their role in neurodegeneration, indicating that this approach has potential for success.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Vidal, Ruben — Indiana University Indianapolis
- Study coordinator: Vidal, Ruben
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.