Understanding the structure of alpha-synuclein in Lewy body dementia
Structural Biology of Alpha-Synuclein in Lewy Body Dementia
['FUNDING_OTHER'] · WASHINGTON UNIVERSITY · NIH-10729722
This study is looking at a protein called alpha-synuclein that plays a role in Lewy body dementia, which is often linked to Parkinson's disease, to help find better ways to diagnose and treat the condition.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WASHINGTON UNIVERSITY (nih funded) |
| Locations | 1 site (SAINT LOUIS, UNITED STATES) |
| Trial ID | NIH-10729722 on ClinicalTrials.gov |
What this research studies
This research investigates the role of alpha-synuclein fibrils in Lewy body dementia, a condition often associated with Parkinson's disease. By using advanced techniques like cryo-electron microscopy and solid-state NMR, the researchers aim to determine the atomic structure of these fibrils. This understanding could help in developing targeted therapies and imaging agents to better diagnose and treat the disease. Patients may benefit from insights into how alpha-synuclein contributes to dementia and potential new treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Lewy body dementia or Parkinson's disease with dementia.
Not a fit: Patients with other forms of dementia unrelated to alpha-synuclein accumulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and targeted therapies for Lewy body dementia.
How similar studies have performed: Previous research has shown promise in understanding alpha-synuclein's role in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
SAINT LOUIS, UNITED STATES
- WASHINGTON UNIVERSITY — SAINT LOUIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOTZBAUER, PAUL T — WASHINGTON UNIVERSITY
- Study coordinator: KOTZBAUER, PAUL T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.