Understanding the structure of a protein linked to Parkinson's Disease
Official title: Structural analysis of the human LRRK2
Funded at St. Jude Children's Research Hospital · NIH-11085993 · Data updated 2026-11-12
This study is looking at a protein called LRRK2 that plays a role in Parkinson's Disease, and by understanding how it works, researchers hope to find new ways to help manage or even prevent the condition for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | St. Jude Children's Research Hospital NIH-funded |
| Lab location | 1 site (Memphis, United States) |
| Project start | May 17, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $455,000 |
| NIH project number | 5R01NS129795-03 |
| Project ID | NIH-11085993 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's Disease, particularly those with known LRRK2 mutations.
✕Less likely to help
Patients with Parkinson's Disease not associated with LRRK2 mutations may not benefit directly from this research.
What this research studies
This research investigates the structure and function of the LRRK2 protein, which is associated with Parkinson's Disease (PD). By using advanced techniques like cryo-electron microscopy, the researchers aim to uncover how LRRK2 operates at a molecular level, particularly how it is activated and interacts with other cellular components. This understanding could lead to the development of new treatments targeting LRRK2 to help manage or potentially prevent PD. Patients may benefit from insights gained that could inform future therapies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for Parkinson's Disease, improving the quality of life for patients.
How similar studies have gone: Previous research has shown promise in targeting LRRK2 for therapeutic development, indicating that this approach has potential based on earlier successes.
Where this research is happening
-
St. Jude Children's Research Hospital
Memphis, United States Active
Researchers
- Principal investigator: Lee, Chia-Hsueh — St. Jude Children's Research Hospital
- Study coordinator: Lee, Chia-Hsueh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.