Understanding the structure and function of the periodontal ligament
Non uniformity in the PDL: structure and function of the dense collar
['FUNDING_R01'] · TUFTS UNIVERSITY BOSTON · NIH-10908373
This study is looking at a special part of the tissue that helps hold your teeth in place, with the goal of finding new ways to help repair it, so you can enjoy better dental health and keep your teeth strong for longer.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TUFTS UNIVERSITY BOSTON (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10908373 on ClinicalTrials.gov |
What this research studies
This research investigates the periodontal ligament (PDL), a crucial soft tissue that connects teeth to the alveolar bone and allows for efficient chewing. The study focuses on a specific part of the PDL known as the dense collar, which has a unique structure and plays a vital role in tooth stability. By examining the dense collar's composition and mechanical properties, the research aims to develop new therapies for regenerating the PDL, which is currently challenging to restore. Patients may benefit from advancements in dental treatments that enhance tooth function and longevity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with periodontal disease or those requiring dental restoration treatments.
Not a fit: Patients with healthy periodontal tissues or those without dental issues may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for regenerating the periodontal ligament, enhancing dental health and tooth longevity.
How similar studies have performed: While there has been some research on periodontal tissue regeneration, the specific focus on the dense collar structure is a novel approach that has not been extensively tested.
Where this research is happening
BOSTON, UNITED STATES
- TUFTS UNIVERSITY BOSTON — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NAVEH, GILI RINA — TUFTS UNIVERSITY BOSTON
- Study coordinator: NAVEH, GILI RINA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.