Understanding the structure and function of the Lujo virus glycoprotein
Official title: Illuminating Lujo virus glycoprotein structure, receptor engagement and neutralizing antibody epitopes
Funded at La Jolla Institute for Immunology · NIH-10991727 · Data updated 2026-11-12
This study is looking at a part of the Lujo virus that causes serious illness, to understand how it works and find ways to create treatments or vaccines that could help people who get infected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | La Jolla Institute for Immunology NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | November 24, 2023 |
| Project end | October 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $221,888 |
| NIH project number | 5R21AI180853-02 |
| Project ID | NIH-10991727 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals at risk of exposure to the Lujo virus or those living in regions where this virus is prevalent.
✕Less likely to help
Patients who are not at risk of exposure to the Lujo virus or who do not live in affected regions may not receive any benefit from this research.
What this research studies
This research investigates the glycoprotein of the Lujo virus, which is responsible for severe hemorrhagic fever. By examining its structure and how it interacts with receptors on human cells, the study aims to identify potential targets for neutralizing antibodies. The approach involves advanced biochemical and biophysical techniques to analyze the virus's unique properties. This knowledge could lead to the development of effective treatments or vaccines for infections caused by this and similar viruses.
Why it matters
Potential benefit: If successful, this research could lead to new therapies or vaccines that significantly reduce the mortality rate associated with Lujo virus and other related hemorrhagic fevers.
How similar studies have gone: Other research on the structure and function of viral glycoproteins has shown promise in developing effective vaccines and treatments, indicating that this approach could be successful.
Where this research is happening
-
La Jolla Institute for Immunology
La Jolla, United States Active
Researchers
- Principal investigator: Hastie, Kathryn Marie — La Jolla Institute for Immunology
- Study coordinator: Hastie, Kathryn Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.