Understanding the structure and function of the human placenta and its role in pregnancy complications
Cellular Atlas of the Human Placenta: Structure-Function Relationships and their Implications for Placental Dysfunction
This study is looking at how the placenta works and what happens when there are problems during pregnancy, like preeclampsia or when a baby isn't growing as it should, to help us understand how to improve health for both moms and babies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project ID | NIH-10876943 on NIH RePORTER |
What this research studies
This research investigates the complex relationships between the structure and function of the human placenta, particularly in the context of pregnancy complications such as preeclampsia and fetal growth restriction. By utilizing advanced technologies like single-cell RNA sequencing, the study aims to characterize the different cell types within the placenta and their roles in placental dysfunction. The research will also explore how these cellular changes correlate with maternal and neonatal health outcomes, providing insights into potential interventions. Patients may benefit from a better understanding of placental health and its impact on pregnancy.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals experiencing complications such as preeclampsia or fetal growth restriction.
Not a fit: Patients with uncomplicated pregnancies or those not experiencing placental dysfunction may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatments for pregnancy-related complications linked to placental dysfunction.
How similar studies have performed: Other research has shown promise in understanding placental function through advanced cellular analysis, suggesting that this approach could yield valuable insights.
Where this research is happening
La Jolla, United States
- University of California, San Diego — La Jolla, United States (Active)
Researchers
- Principal investigator: Parast, Mana M — University of California, San Diego
- Study coordinator: Parast, Mana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.