Understanding the structure and function of the cell nucleus
Multiscale Analyses of 4D Nucleome Structure and Function by Comprehensive Multimodal Data Integration
This study is exploring how the parts of the cell's nucleus work together and change over time, which could help us understand more about health and diseases, so patients can benefit from new insights into how their cells function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Carnegie-Mellon University NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10931439 on NIH RePORTER |
What this research studies
This research investigates the complex organization of the cell nucleus, which plays a crucial role in cellular functions and health. By integrating advanced imaging techniques and genomic data, the project aims to create detailed 4D maps of nuclear structures and their dynamics. This approach will help uncover how different components of the nucleus interact and influence gene function, particularly in relation to health and disease. Patients may benefit from insights gained about nuclear organization and its implications for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic disorders or diseases that may be influenced by nuclear structure and function.
Not a fit: Patients with conditions unrelated to genomic organization or nuclear function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding of how nuclear structure affects health, potentially informing treatments for diseases linked to genomic organization.
How similar studies have performed: Other research has shown success in using imaging and genomic integration to study cellular structures, suggesting that this approach has potential for meaningful discoveries.
Where this research is happening
Pittsburgh, United States
- Carnegie-Mellon University — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Ma, Jian — Carnegie-Mellon University
- Study coordinator: Ma, Jian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.