Understanding the structure and function of tau protein in Alzheimer's disease
Structure and Function of Tau
['FUNDING_R01'] · WEILL MEDICAL COLL OF CORNELL UNIV · NIH-10875698
This study is looking at a protein called tau that plays a role in Alzheimer's disease, and it's trying to understand how certain forms of this protein can harm brain cells, with the hope of finding new ways to help people with Alzheimer's.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WEILL MEDICAL COLL OF CORNELL UNIV (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10875698 on ClinicalTrials.gov |
What this research studies
This research investigates the tau protein, which forms neurofibrillary tangles in Alzheimer's disease, contributing to cognitive decline. The project aims to uncover the structure of toxic tau oligomers that may lead to neuronal death, using advanced techniques like solid-state NMR and ESR spectroscopy. By understanding how these oligomers form and their interactions, the research hopes to shed light on the mechanisms of neurodegeneration in Alzheimer's disease. This could ultimately lead to new therapeutic strategies to combat the disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it due to genetic factors.
Not a fit: Patients with other forms of dementia unrelated to tau pathology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that target tau protein aggregation, potentially slowing or halting the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding tau pathology, but the specific focus on toxic tau oligomers is a novel approach.
Where this research is happening
NEW YORK, UNITED STATES
- WEILL MEDICAL COLL OF CORNELL UNIV — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELIEZER, DAVID — WEILL MEDICAL COLL OF CORNELL UNIV
- Study coordinator: ELIEZER, DAVID
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease brain