Understanding the structure and function of chromosomes during cell division
Structure and Pharmacologic Modulation of the Mitotic Chromosome's Central Axis
This study is looking at how chromosomes are built and organized when cells divide, using special imaging tools to better understand their structure, which could help us learn more about how genetic information is shared correctly during this process.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10918346 on NIH RePORTER |
What this research studies
This research investigates how chromosomes are formed and organized during cell division, focusing on the central axis that supports their structure. By using advanced imaging techniques, the study aims to uncover the molecular makeup and three-dimensional architecture of this central scaffold. The findings could enhance our understanding of chromosome behavior, which is crucial for accurate genetic information distribution during cell division. This research may also explore how these structures interact with surrounding chromatin, providing insights into cellular processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or genetic disorders that involve chromosomal instability.
Not a fit: Patients with stable chromosomal conditions or those not affected by chromosomal abnormalities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of chromosomal behavior in cancer and other diseases, potentially informing new therapeutic strategies.
How similar studies have performed: Other research has shown success in understanding chromosomal structures using advanced imaging techniques, suggesting that this approach is promising.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Beel, Andrew J. — Stanford University
- Study coordinator: Beel, Andrew J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.