Understanding the structure and dynamics of the nucleosome core particle
Official title: Computational Methods to Characterize Structure and Dynamics of the Nucleosome Core Particle
Funded at College of Staten Island · NIH-10442803 · Data updated 2026-11-12
This study is looking at how the building blocks of DNA, called nucleosome core particles, work and change, which could help us understand gene activity and how certain changes can lead to diseases like cancer, ultimately helping patients by uncovering new ways to tackle these conditions.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Staten Island NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2022 |
| Project end | May 31, 2026 |
| Funding year | 2022 |
| Award (this year) | $494,386 |
| NIH project number | 1R15GM146228-01 |
| Project ID | NIH-10442803 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with genetic mutations related to chromatin structure or those diagnosed with cancers influenced by epigenetic factors.
✕Less likely to help
Patients with conditions unrelated to chromatin dynamics or those not affected by genetic mutations in nucleosome components may not benefit from this research.
What this research studies
This research investigates the nucleosome core particle (NCP), which is essential for DNA packaging and gene regulation. By using advanced computational methods, the study aims to characterize how the NCP's structure and dynamics affect its function in gene activity and its role in diseases like cancer. The approach involves developing new techniques to analyze the interactions between DNA and histone proteins, which are crucial for understanding how genetic information is accessed and regulated. Patients may benefit from insights gained into how mutations in these structures can lead to malignancies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cancer by understanding the fundamental mechanisms of gene regulation.
How similar studies have gone: Other research has shown promising results in understanding chromatin dynamics and its implications in cancer, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
-
College of Staten Island
New York, United States Active
Researchers
- Principal investigator: Loverde, Sharon Marie — College of Staten Island
- Study coordinator: Loverde, Sharon Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.