Understanding the structure and dynamics of disordered proteins in the body
Official title: Intrinsically Disordered Protein Structural Dynamics from Combined Solution and Gas-Phase Approaches
Funded at Indiana University Indianapolis · NIH-11060025 · Data updated 2026-11-12
This study is looking at special proteins that don’t have a set shape and are connected to serious health issues, and it aims to create better ways to understand how these proteins work and change, which could help us learn more about their impact on our health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | July 15, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $384,483 |
| NIH project number | 5R35GM151251-03 |
| Project ID | NIH-11060025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by degenerative diseases linked to protein misfolding, such as neurodegenerative disorders.
✕Less likely to help
Patients with conditions unrelated to protein misfolding or those not affected by degenerative diseases may not benefit from this research.
What this research studies
This research investigates intrinsically disordered proteins (IDPs), which are proteins that do not have a fixed structure and are linked to various serious diseases. The study aims to develop advanced techniques to analyze these proteins using native ion mobility/mass spectrometry combined with molecular dynamics. By characterizing the structural ensembles of IDPs and understanding how modifications affect their behavior, the research seeks to fill the gap in current biophysical tools that struggle to provide detailed insights into these proteins. This could lead to a better understanding of their role in health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for diseases associated with protein misfolding.
How similar studies have gone: Previous research has shown promise in using advanced biophysical techniques to study protein structures, indicating that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Webb, Ian — Indiana University Indianapolis
- Study coordinator: Webb, Ian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.