Understanding the spike protein of the SARS-CoV-2 virus
Structure and Dynamics of the SARS-CoV-2 Spike Protein
['FUNDING_R01'] · YALE UNIVERSITY · NIH-10868635
This study is looking at a part of the COVID-19 virus that helps it enter our cells, to better understand how it interacts with our immune system, which could lead to better vaccines for everyone.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | YALE UNIVERSITY (nih funded) |
| Locations | 1 site (NEW HAVEN, UNITED STATES) |
| Trial ID | NIH-10868635 on ClinicalTrials.gov |
What this research studies
This research focuses on the spike protein of the SARS-CoV-2 virus, which is crucial for the virus's ability to enter human cells. By examining the structure and dynamics of this protein, researchers aim to understand how it interacts with antibodies, which is essential for developing effective vaccines. The study employs advanced imaging techniques, such as cryo-electron microscopy, to visualize the protein in different conformations. This knowledge could help in designing vaccines that elicit strong immune responses against COVID-19.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in participating in vaccine trials or those who are at high risk for COVID-19.
Not a fit: Patients who have already been vaccinated or those with no exposure to COVID-19 may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective vaccines against COVID-19.
How similar studies have performed: Previous research on viral spike proteins has shown promise in vaccine development, indicating that this approach is both relevant and potentially impactful.
Where this research is happening
NEW HAVEN, UNITED STATES
- YALE UNIVERSITY — NEW HAVEN, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOTHES, WALTHER H — YALE UNIVERSITY
- Study coordinator: MOTHES, WALTHER H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.