Understanding the signals that lead to early Type 1 diabetes progression
Determining the Intrinsic and Environmental Signal Contributing to Early T1D Progression
This study is looking at how signals from both the pancreas and the immune system affect the development of Type 1 diabetes, with the hope of finding new ways to treat the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10653103 on NIH RePORTER |
What this research studies
This research investigates how both internal signals from pancreatic beta cells and external signals from immune cells contribute to the progression of Type 1 diabetes (T1D). By analyzing samples from healthy individuals and those with autoantibodies, the team aims to uncover the molecular mechanisms that lead to beta cell dysfunction and death. They utilize advanced techniques such as single-cell transcriptome profiling and stem cell-derived pancreatic cells to explore these dynamics. The goal is to create a comprehensive understanding of T1D progression that could inform future treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are at risk for Type 1 diabetes, particularly those with autoantibodies but not yet diagnosed with diabetes.
Not a fit: Patients who are already diagnosed with advanced Type 1 diabetes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Type 1 diabetes.
How similar studies have performed: Previous research has shown promise in understanding autoimmune responses in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Chen, Shuibing — Weill Medical Coll of Cornell Univ
- Study coordinator: Chen, Shuibing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.