Understanding the shared risks of brain arteriolosclerosis and related conditions
Elucidating Shared Risk of Brain Arteriolosclerosis and Related Pathologies with Multiple 'omics Modalities
['FUNDING_FELLOWSHIP'] · UNIVERSITY OF KENTUCKY · NIH-11081793
This study is looking into how thickening of small blood vessels in the brain, which can affect thinking and memory in older adults, happens and what might cause it, and we invite patients to share their genetic information to help us learn more about keeping brains healthy as we age.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF KENTUCKY (nih funded) |
| Locations | 1 site (LEXINGTON, UNITED STATES) |
| Trial ID | NIH-11081793 on ClinicalTrials.gov |
What this research studies
This research investigates brain arteriolosclerosis (B-ASC), a condition that leads to thickening of the brain's arterioles and is linked to cognitive decline in older adults. By analyzing genetic and autopsy data from multiple cohorts, the study aims to uncover the underlying mechanisms and risk factors associated with B-ASC and its relationship to other brain pathologies. Patients may be involved in providing genetic samples or data that can help identify these risk factors, contributing to a better understanding of cognitive health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults, particularly those aged 65 and above, who may be experiencing cognitive decline or have a family history of related conditions.
Not a fit: Patients under the age of 65 or those without any cognitive decline or related neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating cognitive decline associated with brain arteriolosclerosis.
How similar studies have performed: Previous research has shown promising results in understanding genetic factors related to brain pathologies, suggesting that this approach may yield valuable insights.
Where this research is happening
LEXINGTON, UNITED STATES
- UNIVERSITY OF KENTUCKY — LEXINGTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHADE, LINCOLN — UNIVERSITY OF KENTUCKY
- Study coordinator: SHADE, LINCOLN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.