Understanding the SCP4 protein in acute myeloid leukemia
Elucidating the SCP4 pathway as a multi-catalytic signaling dependency in acute myeloid leukemia
This research explores a specific protein called SCP4 and its partners to find new ways to treat acute myeloid leukemia, a type of blood cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11142568 on NIH RePORTER |
What this research studies
Our team is looking into a protein called SCP4, which appears to be very important for the survival of acute myeloid leukemia (AML) cells, but not for healthy blood cells. We've found that SCP4 works closely with two other proteins, STK35 and PDIK1L, helping them function in a way that supports AML. We want to understand exactly how these proteins interact and what role they play in the disease. By uncovering these details, we hope to identify new targets for medicines that could specifically stop AML cells from growing.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biology of acute myeloid leukemia, and while not directly recruiting patients, it is relevant for individuals living with or at risk for AML.
Not a fit: Patients with conditions other than acute myeloid leukemia would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to the development of new, more targeted treatments for acute myeloid leukemia by disrupting a critical pathway that cancer cells rely on.
How similar studies have performed: While SCP4 itself is poorly studied, targeting phosphatases and kinases, the class of proteins involved here, has shown success in other cancer treatments, suggesting a promising approach.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Vakoc, Christopher — Cold Spring Harbor Laboratory
- Study coordinator: Vakoc, Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.