Understanding the roles of specific proteins in tooth enamel and dentin formation
Functions of Family with Sequence Similarity 20 - Member C (FAM20C) andMember A (FAM20A) in Amelogenesis and Dentinogenesis
This study is looking at two important proteins that help make your teeth strong and healthy, and it aims to understand how they work together, which could lead to better treatments for dental issues in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University Health Science Ctr NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-10685371 on NIH RePORTER |
What this research studies
This research investigates the functions of two proteins, FAM20C and FAM20A, which are crucial for the development of tooth enamel and dentin. By exploring how these proteins interact and are retained in cells, the study aims to uncover the molecular mechanisms behind tooth formation. The research involves both in vitro and in vivo approaches to assess the impact of these proteins on ameloblasts and odontoblasts, the cells responsible for enamel and dentin production. Patients may benefit from insights gained into genetic factors affecting tooth development and potential treatments for dental defects.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic mutations affecting tooth enamel or dentin formation.
Not a fit: Patients with dental issues unrelated to genetic factors affecting enamel or dentin formation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for dental enamel and dentin defects.
How similar studies have performed: Other research has shown promising results in understanding the roles of proteins in tooth development, suggesting that this approach could yield valuable insights.
Where this research is happening
College Station, United States
- Texas A&m University Health Science Ctr — College Station, United States (Active)
Researchers
- Principal investigator: Lu, Yongbo — Texas A&m University Health Science Ctr
- Study coordinator: Lu, Yongbo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.