Understanding the roles of specific proteins in cellular stress responses
Official title: Signaling, Sensing, and Enzymatic Roles of Disordered Selenoproteins
Funded at University of Delaware · NIH-10842544 · Data updated 2026-11-12
This study is looking at two proteins that help our cells handle stress, and it aims to understand how they might be connected to diseases like diabetes, cancer, and heart problems, which could lead to better ways to manage these conditions for patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Delaware NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | August 15, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $362,932 |
| NIH project number | 1R35GM153494-01 |
| Project ID | NIH-10842544 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for or diagnosed with adult-onset diabetes, cardiovascular diseases, or certain cancers.
✕Less likely to help
Patients with conditions unrelated to cellular stress responses or those not at risk for the studied diseases may not benefit from this research.
What this research studies
This research investigates the functions of two proteins, selenoprotein K and selenoprotein S, which are involved in how cells respond to stress. The study aims to explore how these proteins contribute to various cellular processes, including protein quality control and gene expression. By examining their interactions and roles within the cell, the research seeks to uncover their potential links to diseases such as diabetes, cancer, and cardiovascular conditions. Patients may benefit from insights gained about these proteins and their implications for disease management.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating diseases like diabetes and cancer.
How similar studies have gone: Previous research has shown promising results in understanding the roles of selenoproteins in cellular processes, suggesting potential for success in this area.
Where this research is happening
-
University of Delaware
Newark, United States Active
Researchers
- Principal investigator: Rozovsky, Sharon — University of Delaware
- Study coordinator: Rozovsky, Sharon
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.