Understanding the roles of osteocalcin in the body
Skeletal and non-skeletal roles for osteocalcin
This study is looking at a protein called osteocalcin, which is mostly found in bones, to see how it might affect things like blood sugar, fat storage, fertility, muscle strength, and brain growth, and it could help us understand how this protein impacts health and disease for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10818553 on NIH RePORTER |
What this research studies
This research investigates the protein osteocalcin, which is primarily found in bone, and its potential roles as a hormone that may influence various bodily functions such as glucose metabolism, fat storage, fertility, muscle mass, and brain development. By studying different strains of osteocalcin knockout mice, the research aims to clarify conflicting results from previous studies regarding how osteocalcin affects these processes. The approach involves comparing the effects of genetic variations and environmental factors on the physiological roles of osteocalcin. Patients may benefit from insights gained about how osteocalcin influences health and disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include children and young adults with metabolic disorders, fertility issues, or cognitive challenges.
Not a fit: Patients with conditions unrelated to bone health, metabolism, or cognitive function may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new understanding and treatments for conditions related to metabolism, fertility, and cognitive function.
How similar studies have performed: Previous studies have shown varying results regarding the role of osteocalcin, indicating that while this area of research has been explored, the findings remain inconclusive and warrant further investigation.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Warman, Matthew L — Boston Children's Hospital
- Study coordinator: Warman, Matthew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.