Understanding the roles of immune cells in eosinophilic gastrointestinal disorders
Official title: Deciphering the roles of eosinophils and T lymphocytes in EGID
Funded at Northwestern University at Chicago · NIH-11017711 · Data updated 2026-11-12
This study is looking at how certain immune cells, called eosinophils and T lymphocytes, behave in people with eosinophilic gastrointestinal disorders (EGIDs) to help us understand the condition better and find new ways to diagnose and treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University at Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | February 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $190,981 |
| NIH project number | 5K23AI171085-03 |
| Project ID | NIH-11017711 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with eosinophilic gastrointestinal disorders, including eosinophilic esophagitis and eosinophilic gastritis/duodenitis.
✕Less likely to help
Patients with eosinophilic disorders not affecting the gastrointestinal tract or those with other unrelated conditions may not benefit from this research.
What this research studies
This research investigates the roles of eosinophils and T lymphocytes in eosinophilic gastrointestinal disorders (EGIDs), which are inflammatory conditions characterized by an excessive number of eosinophils in the gastrointestinal tract. The study aims to uncover the unique characteristics of these immune cells in EGIDs compared to other eosinophilic disorders, focusing on their involvement in the disease's progression and symptoms. By examining the cellular and molecular mechanisms at play, the research seeks to improve understanding of how these immune responses contribute to the condition. This could lead to better diagnostic and therapeutic strategies for patients suffering from EGIDs.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and management strategies for patients with eosinophilic gastrointestinal disorders.
How similar studies have gone: Previous research has shown promise in understanding immune cell roles in other allergic diseases, suggesting potential for success in this novel investigation of EGIDs.
Where this research is happening
-
Northwestern University at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Kuang, Fei Li — Northwestern University at Chicago
- Study coordinator: Kuang, Fei Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.