Understanding the role of TDP-43 protein in neurodegenerative diseases
Official title: Investigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathies
Funded at Indiana University Indianapolis · NIH-11075368 · Data updated 2026-11-12
This study is looking at how changes in a protein called TDP-43 might cause problems in the brain for people with certain neurodegenerative diseases, especially those affecting memory and behavior, to help find better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | April 16, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $980,431 |
| NIH project number | 5R01NS137469-02 |
| Project ID | NIH-11075368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with frontotemporal lobar degeneration or related neurodegenerative conditions.
✕Less likely to help
Patients with neurodegenerative diseases not associated with TDP-43 proteinopathies may not benefit from this research.
What this research studies
This research investigates how the mislocalization and structural changes of the TDP-43 protein contribute to various neurodegenerative diseases, particularly those related to frontotemporal lobar degeneration. By examining the molecular mechanisms and post-translational modifications of TDP-43, the study aims to uncover why certain brain regions are more affected than others. The research employs advanced techniques such as fluorescent multiplex immunohistochemistry and cryo-electron microscopy to analyze brain tissue samples from affected individuals. Patients may benefit from insights gained into the disease processes, potentially leading to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with neurodegenerative diseases linked to TDP-43.
How similar studies have gone: Previous research has shown promising results in understanding protein misfolding in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Newell, Kathy L — Indiana University Indianapolis
- Study coordinator: Newell, Kathy L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.