Understanding the role of Tau protein in brain cells
Official title: Functions of Tau protein in human neural cells
Funded at University of Washington · NIH-10823285 · Data updated 2026-11-12
This study is looking at how a protein called Tau works in brain cells and how changes in its behavior, especially due to genetic mutations, might play a role in diseases like Alzheimer's, helping us understand more about these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $208,625 |
| NIH project number | 5R21AG079161-02 |
| Project ID | NIH-10823285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors.
✕Less likely to help
Patients with neurodegenerative diseases unrelated to Tau protein or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates how Tau protein, which is important for neuron function, behaves in human neural cells, particularly in the context of neurodegenerative diseases like Alzheimer's. The study aims to clarify the effects of genetic mutations on Tau protein's function and how these changes may contribute to cell dysfunction and disease progression. By examining Tau's interactions and roles in various brain cell types, the research seeks to uncover new insights into its involvement in Alzheimer's and related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating Alzheimer's disease and other neurodegenerative disorders.
How similar studies have gone: Previous studies have shown promising results in understanding Tau protein's role in neurodegeneration, indicating that this research builds on established findings.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Young, Jessica Elaine — University of Washington
- Study coordinator: Young, Jessica Elaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.