Understanding the role of Synaptotagmin VII in brain signaling
Official title: Determining the cellular and nanoscale localization of Synaptotagmin VII
Funded at Thomas Jefferson University · NIH-10983791 · Data updated 2026-11-12
This study is looking at a protein called Synaptotagmin VII (SYT7) that helps send signals in the brain, and it's for anyone interested in understanding how this protein works in brain cells, which could help us learn more about conditions like cancer and ALS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | December 5, 2022 |
| Project end | July 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $53,974 |
| NIH project number | 5F30NS130973-03 |
| Project ID | NIH-10983791 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with neurological or psychiatric conditions linked to synaptic dysfunction, such as bipolar disorder or ALS.
✕Less likely to help
Patients with conditions unrelated to synaptic dysfunction or those not experiencing neurological or psychiatric symptoms may not benefit from this research.
What this research studies
This research investigates the function of Synaptotagmin VII (SYT7), a protein involved in the release of neurotransmitters in the brain. By using advanced microscopy techniques and biochemical methods, the study aims to determine where SYT7 is located within neurons and how it interacts at synapses. This could provide insights into its role in various neurological and psychiatric conditions, including cancer and ALS. The research will involve experiments on mouse and rat brain cells to observe SYT7's behavior in real-time.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of synaptic dysfunction, potentially informing new treatments for neurological and psychiatric disorders.
How similar studies have gone: While the specific focus on SYT7 is less explored, similar studies on other Synaptotagmins have shown promising results in understanding synaptic mechanisms.
Where this research is happening
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Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Cain, Rachel — Thomas Jefferson University
- Study coordinator: Cain, Rachel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.