Understanding the role of Superoxide Dismutase I in Parkinson's Disease
Official title: Investigation of Superoxide Dismutase I in Parkinson's Disease
Funded at Mc Laughlin Research Institute · NIH-11004637 · Data updated 2026-11-12
This study is looking at how a protein called SOD1 interacts with another protein linked to Parkinson's Disease, and it aims to understand how these interactions might affect the progression of the disease, with the help of patients who can provide samples or share their experiences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mc Laughlin Research Institute NIH-funded |
| Lab location | 1 site (Great Falls, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $360,000 |
| NIH project number | 5P20GM152335-02 |
| Project ID | NIH-11004637 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Parkinson's Disease, particularly those with genetic factors related to alpha synuclein.
✕Less likely to help
Patients with Parkinson's Disease who do not have any genetic mutations or variants related to alpha synuclein may not benefit from this research.
What this research studies
This research investigates how Superoxide Dismutase 1 (SOD1) interacts with alpha synuclein in Parkinson's Disease (PD). By examining brain tissue from PD patients, the study aims to uncover the relationship between SOD1 aggregates and the progression of the disease. The approach includes analyzing genetic factors and protein interactions that may contribute to neurodegeneration. Patients may be involved in providing biological samples or participating in assessments related to their condition.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the mechanisms of Parkinson's Disease and potential therapeutic targets.
How similar studies have gone: Previous research has shown that investigating protein interactions in neurodegenerative diseases can yield significant insights, suggesting this approach may be promising.
Where this research is happening
-
Mc Laughlin Research Institute
Great Falls, United States Active
Researchers
- Principal investigator: Leavens, Moses — Mc Laughlin Research Institute
- Study coordinator: Leavens, Moses
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.