Understanding the role of specific retinal cells in vision processing
The function of wide-field amacrine cells in mammalian retina
This study is looking at how a special protein called TPBG affects certain cells in the eye that help us see better, especially when it comes to noticing differences in light and dark. By changing the genes in mice, the researchers want to understand what happens to these cells and our vision when TPBG is missing.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10925407 on NIH RePORTER |
What this research studies
This research investigates the function of wide-field amacrine cells in the mammalian retina, focusing on a specific protein called trophoblast glycoprotein (TPBG). By using genetic manipulation in mice, the study aims to explore how the absence of TPBG affects the excitability of these retinal cells and their role in processing visual information, particularly in enhancing contrast sensitivity. The researchers will employ advanced techniques such as electrophysiology to analyze the cellular and behavioral impacts of these changes. This work seeks to unravel the complexities of retinal neuron interactions and their contributions to vision.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who may have conditions affecting their vision or are interested in the underlying mechanisms of retinal processing.
Not a fit: Patients with no retinal issues or those under 21 years old may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for visual disorders related to retinal function.
How similar studies have performed: While the specific approach of studying TPBG in wide-field amacrine cells is novel, similar research has shown promise in understanding retinal neuron functions.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Chen, Ching-Kang Jason — University of Texas Hlth Science Center
- Study coordinator: Chen, Ching-Kang Jason
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.