Understanding the role of specific genes in lupus
Official title: Contributions of autophagy-related genes in lupus
Funded at Oklahoma Medical Research Foundation · NIH-10910099 · Data updated 2026-11-12
This study is looking at how certain genes related to a process called autophagy might affect lupus, a serious autoimmune disease, and it aims to help us understand why some people have more severe symptoms than others, so if you're a lupus patient, you might be asked to share a genetic sample or take part in research to help with this important work.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | August 18, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $737,750 |
| NIH project number | 5R01AI172255-02 |
| Project ID | NIH-10910099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with systemic lupus erythematosus, particularly those from Asian, African-American, and Hispanic backgrounds.
✕Less likely to help
Patients with lupus who do not have genetic variations related to autophagy may not benefit directly from this research.
What this research studies
This research investigates how autophagy-related genes contribute to systemic lupus erythematosus (SLE), a serious autoimmune disease. By examining the genetic factors and their effects on immune responses, the study aims to uncover the mechanisms that lead to the development and severity of lupus. The research will utilize genetic analysis and animal models to explore the relationship between these genes and the clinical manifestations of the disease, particularly in diverse populations. Patients may be involved in providing genetic samples or participating in studies that assess the impact of these genes on their condition.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for lupus, improving outcomes for patients.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Oklahoma Medical Research Foundation
Oklahoma City, United States Active
Researchers
- Principal investigator: Nath, Swapan K. — Oklahoma Medical Research Foundation
- Study coordinator: Nath, Swapan K.
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.