Understanding the role of specific brain cells in motivation and behavior
Synaptic organization of cholinergic interneurons in the nucleus accumbens
['FUNDING_R21'] · NEW YORK UNIVERSITY · NIH-11217882
This study is looking at special brain cells called cholinergic interneurons that play a key role in motivation and can be affected by substance use disorders, to understand how they work with other brain cells and influence behavior, which could help us learn more about addiction.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11217882 on ClinicalTrials.gov |
What this research studies
This research investigates cholinergic interneurons (CINs) in the nucleus accumbens, a brain region crucial for motivated behaviors and often affected in substance use disorders. The study aims to explore how these rare cells, which are the only source of acetylcholine in the striatum, interact with other brain cells and influence behavior. By using advanced techniques like slice electrophysiology and optogenetics, researchers will analyze the connections and firing patterns of CINs in different parts of the nucleus accumbens. This work could provide insights into the underlying mechanisms of motivation and addiction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with substance use disorders or those interested in understanding the neurobiological basis of motivation.
Not a fit: Patients with conditions unrelated to motivation or substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating substance use disorders and improving motivation-related behaviors.
How similar studies have performed: Previous research has shown promising results in understanding the role of cholinergic interneurons in other brain regions, suggesting potential for success in this novel investigation.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CARTER, ADAM G — NEW YORK UNIVERSITY
- Study coordinator: CARTER, ADAM G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.