Understanding the role of specific brain cells in adult-onset dystonia
Official title: The Role of Striatal Cholinergic Interneurons in Dystonia
Funded at Washington University · NIH-11000785 · Data updated 2026-11-12
This study is looking at how certain brain cells might play a role in causing adult-onset dystonia, a condition that leads to unwanted muscle movements, and aims to find better treatments by understanding how these cells work in the brain.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $550,708 |
| NIH project number | 5R01NS124789-04 |
| Project ID | NIH-11000785 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with adult-onset dystonia.
✕Less likely to help
Patients with dystonia caused by genetic factors or those under 21 years old may not benefit from this research.
What this research studies
This research investigates how striatal cholinergic interneurons (ChIs) contribute to the development of adult-onset dystonia, a movement disorder characterized by involuntary muscle contractions. By using advanced imaging techniques like PET scans and MRI, the study aims to identify common mechanisms across different types of dystonia, which could lead to more effective treatments. The research focuses on the biochemical and network-level dysfunctions associated with these brain cells, potentially guiding future therapeutic interventions. Patients may benefit from a better understanding of their condition and the development of targeted therapies based on the findings.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for adult-onset dystonia and improve patient outcomes.
How similar studies have gone: Previous research has shown promise in understanding the role of cholinergic interneurons in movement disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Norris, Scott Allen — Washington University
- Study coordinator: Norris, Scott Allen
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.